Ibogaine has affinity (Ki) for the following sites in decreasing order of potency: σ2 (206 nM) > SERT (548.7 nM) > DAT (1,980 nM) > NMDA (2,001 nM) > κ-opioid (2,717 nM) > µ-opioid (4,362 nM) > σ1 (5,839 nM) > M3 (12,500 nM) > 5-HT2A (14,142 nM) > M1 (22,486 nM) > M2 (39,409 nM) > D3 (70,000 nM).[42] It also has affinity for VMAT and the nACh receptors, among other targets
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