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Ibogaine – Metabolites

Ibogaine is metabolized in the human body by cytochrome P450 2D6, and the major metabolite is noribogaine (12-hydroxyibogamine). Noribogaine is most potent as a serotonin reuptake inhibitor and acts as a moderate κ- and weak µ-opioid receptor full agonist and therefore, also has an aspect of an opiate replacement similar to compounds like methadone. It is possible that this action of noribogaine at the kappa opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; salvia divinorum, another plant recognized for its strong hallucinogenic properties, contains the chemical salvinorin-A which is a highly selective kappa opioid agonist. Both ibogaine and noribogaine have a plasma half-life of around two hours in the rat, although the half-life of noribogaine is slightly longer than the parent compound. It is proposed that ibogaine is deposited in fat and metabolized into noribogaine as it is shows higher plasma levels than ibogaine and may therefore be detected for longer periods of time than ibogaine. Noribogaine is also more potent than ibogaine in rat drug discrimination assays when tested for the subjective effects of ibogaine. The Noribogaine differs from ibogaine in that it contains a hydroxy instead of a methoxy group at the 12 position
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Ibogaine – Research

An ibogaine research project was funded by the US National Institute on Drug Abuse in the early 1990s. The National Institute on Drug Abuse (NIDA) abandoned efforts to continue this project into clinical studies in 1995, citing other reports that suggested a risk of brain damage with extremely high doses and fatal heart arrhythmia in patients having a history of health problems, as well as inadequate funding for ibogaine development within their budget. However, NIDA funding for ibogaine research continues in indirect grants often cited in peer-reviewed ibogaine publications. In addition, after years of work and a number of significant changes to the original protocol, on August 17, 2006, a MAPS-sponsored research team received "unconditional approval" from a Canadian Institutional Review Board (IRB) to proceed with a long-term observational case study that will examine changes in substance use in 20 consecutive people seeking ibogaine-based therapy for opiate dependence at the Iboga Therapy House in British Columbia, Canada. Addiction treatment The most-studied therapeutic effect of ibogaine is the reduction or elimination of addiction to opioids. An integral effect is the alleviation of symptoms of opioid withdrawal. Research also suggests that ibogaine may be useful in treating dependence on other substances such as alcohol, methamphetamine, and nicotine, and may affect compulsive behavioral patterns not involving substance abuse or chemical dependence. Researchers note that there remains a "need for systematic investigation in a conventional clinical research setting." Many users of ibogaine report experiencing visual phenomena during a waking dream state, such as instructive replays of life events that led to…
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Ibogaine – Legal status

Ibogaine and its salts were regulated by the Food and Drug Administration in 1967 pursuant to its enhanced authority to regulate stimulants, depressants, and hallucinogens granted by the 1965 Drug Abuse Control Amendments (DACA) to the Federal Food, Drug, and Cosmetic Act. In 1970, with the passage of the Controlled Substances Act, it was classified as a Schedule I-controlled substance in the United States, along with other psychedelics such as DMT and mescaline. Since that time, several other countries, including Sweden, Denmark, Belgium, and Switzerland, have also banned the sale and possession of ibogaine. Although illegal in these countries, ibogaine has been used by hundreds of drug dependents in the United States and abroad. Howard Lotsof, a pioneer in bringing awareness to ibogaine's success in helping hardcore drug dependents to quit their addiction, and others have been offering willing persons the treatment. In the Czech Republic and Slovenia, taking advantage of less prohibitive legal systems, ibogaine has been applied to people coming from the and other countries seeking a safe haven.
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Ibogaine – In popular culture

Ibogaine first appeared in popular culture in the writings of Hunter S. Thompson. While covering the Wisconsin primaries of the 1972 Presidential primaries for Rolling Stone magazine, Thompson claimed that presidential candidate Edmund Muskie showed symptoms of being under the influence of Ibogaine. This assertion was later revealed by Thompson to be false, one that he had planted as media bait. He himself was surprised when the leading media outlets picked up the story and ran with it. It also appeared in the seventh episode of the eleventh season of Law & Order: Special Victims Unit. In the episode, Doctor Huang administers Ibogaine to a heroin addict so that he can testify against a murderer
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Ibogaine Treatment

You may apply for an iboga or Ibogaine treatment if you and only you think that you will benefit from having the treatment. This is for your own risk, and given the intensity of the ibogaine  treatment which is a big responsibility that you deliberately take upon yourself. Outside Africa, iboga extracts and purified alkaloids are being used for an Ibogaine treatment. Treatment will last several days, depending whether you’re addicted or not, and what you are addicted to. After the iboga is psychologically prepared, it is usually after three days, one has time to recover. During the dream state you are not able to sleep and one will lose their appetite, so you will could feel weaken the first days after treatment. After first taking a full dose of the Iboga the drug tolerance will be gone, nevertheless taking drugs can have serious consequences. The hallucinogenic effect is very intense. The locomotion is reduced. Iboga visions relate to all five senses. We see flashes and increased sensory perceptions. The visions of “time travel” give insight into personal events of the past and his encounters with archetypal structures deep into the consciousness. This trip is very long time, and it can take up to 40 hours. If you decide to undergo a treatment then we strongly advise you to have your health checked in advance Heart and liver problems or low blood pressure is a contraindication. We also emphasize on the importance that a sober person must be with you,…
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Chemistry of Ibogaine

Recent studies have shown that the primary metabolite from Ibogaine itself interacts with numerous neuron receptor transporters and neuronal networks within the mobile network and in the activity of dopaminergic-dependent and independent modulation circuits. Ibogaine takes the brain activity back into a healthy balance. Ibogaine actions are reported to reduce dopamine concentrations in the body. This is evidenced by the presence of dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in larger quantities after Ibogaine administration. This action of Ibogaine is to reverse the impact of drug abuse of some highly addictive drugs, Name: * Cocaine * Morphine * Amphetamines * Crack cocaine * Nicotine * Alcohol All these drugs act on dopamine dopaminergic systems and stimulate the body. Ibogaine is a tryptamine. It has two separate chiral centers, meaning that there are four different stereoisomers of ibogaine. These four isomers are difficult to resolve. Synthesis One recent total synthesis of ibogaine and related drugs starts with 2-iodo-4-methoxyaniline which is reacted with triethyl((4-(triethylsilyl)but-3-yn-1-yl)oxy)silane using palladium acetate in DMF to form 2-(triethylsilyl)-3-(2-((triethylsilyl)oxy)ethyl)-1H-indole. This is converted using N-iodosuccinamide and then fluoride to form 2-(2-iodo-1H-indol-3-yl)ethanol. This is treated with iodine, triphenyl phosphine, and imidazole to form 2-iodo-3-(2-iodoethyl)-1H-indole. Then, using 7-ethyl-2-azabicyclooct-5-ene and cesium carbonate in acetonitrile, the ibogaine precursor 7-ethyl-2-(2-(2-iodo-1H-indol-3-yl)ethyl)-2-azabicyclooct-5-ene is obtained. Using palladium acetate in DMF, the ibogaine is obtained. If the exo ethyl group on the 2-azabicyclooctane system in ibogaine is replaced with an endo ethyl, then epiibogaine is formed. Crystalline ibogaine hydrochloride is typically produced by semi-synthesis from voacangine in commercial laboratories. Derivatives A synthetic derivative of ibogaine, 18-methoxycoronaridine (18-MC), is a selective α3β4 antagonist that was developed collaboratively by the neurologist Stanley D. Glick…
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What is It Ibogaine?

Ibogaine is the psychoactive alkaloid from the root bark of the African bush Tabernanthe Iboga. Ibogaine is both a therapeutic and psychoactive addiction-breaker. In recent years the knowledge of Ibogaine has increasingly grown in breaking drug and alcohol addiction. Studies show that with only a single administration of Ibogaine, withdrawal symptoms are significantly reduced or in some cases even removed. Research shows that the desire for drug of choice is eliminated for either a long period of time or forever. The psychoactive properties of Ibogaine simulates a high spiritual awareness, It helps you to decipher problems in your life that may have lead you to taking drugs in the first place. Once those problems are identified and understood you can move forward and live drug free lives. Studies endorse that Ibogaine has considerable potential in the treatment of hard drug addiction for example heroin, suboxone, methadone, cocaine, crack and alcohol. There are also indications that it may be useful in the treatment of tobacco addiction. Ibogaine also offers opportunities as psychotherapy and/or spiritual teacher. In the field of psychotherapy, Ibogaine can be used as a treatment for the effects of trauma or conditioning, like asthma, cornice pain etc. The difference between Ibogaine and Iboga root bark is that the root bark alkaloids contain and include the Ibogaine Tabernanthe alkaloids which are extracted from the Iboga root bark. Ibogaine extract contains only scientifically recognized alkaloid with the known actions. Iboga World Iboga World specializes in and is committed to providing HIGH…
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Ibogaine as an addiction breaker

A single administration of Ibogaine has several useful functions in drug treatment. First it causes a huge reduction in withdrawal symptoms, which can be detoxified relatively painless. Secondly, withdrawal symptoms are greatly reduced. The strong desire disappears and gives way to a clear consciousness. Finally, the psychoactive dreams state helps the patients understand underlying issues in their life that may have caused them to start using drugs in order to solve those problems and therefore change their behavior and thus completely eliminate addiction. Please note: Despite the excellent potential which Ibogaine offers to treat addiction, it should be clear that Ibogaine will not help everyone. It is important that there is dedicated motivation and the ability to change the environment. Ibogaine may well break an addiction, but it is not a panacea. One should also take into account that an Ibogaine treatment is very intense way to break an addiction and should not be taken lightly nor for granted. Before you decide to have a Ibogaine treatment, ones health should be examined by a registered doctor. Heart, liver problems or low blood pressure is a contraindication.
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Ibogaine Provider

Iboga World Ibogaine Provider , your supplier of guaranteed high quality Tabernanthe Iboga products. Are you looking for a trustworthy Iboga Provider , who supplies High Quality Tabernanthe Iboga products and delivers what you order? Look no further! Iboga World specializes in Iboga products. Your Ibogaine Provider Iboga World has its own plantations in the country of origin to ensure the best quality and the best price. Quality is assured! This is evident by the positive feedback from the clients, treatment centers as well as individual consumers. Not only will you be receiving a top quality product but we are obligated to supply our customers with what they have ordered and paid for because the customer will be able to complete the transaction online via credit card or direct transfers. Giving you total peace of mind. Iboga World supplies to the most reputable treatment centers in the world The owner is committed to not only helping individuals break the habit but also to enrich their lives after treatment. If you would like more information about the quality of the products you are welcome to contact us Iboga World is a reputable and trustworthy supplier of Iboga and guarantees a quality product. Please visit our website: Ibogaine Provider email us at Kind regards Iboga World Team Your Ibogaine Provider
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