Ibogamine
Ibogamine is an alkaloid found in Tabernanthe iboga.
Basic research related to how addiction affects the brain has used this chemical.
Ibogamine persistently reduced the self-administration of cocaine and morphine in rats.. The same study found that Ibogamine (40mg/kg) and Coronaridine (40mg/kg) did not produce “any tremor effects in rats that differ significantly from saline control”. While the related alkaloids Ibogaine(20-40 mg/kg), harmaline (10-40 mg/kg) and desethylcoronaridine (10-40 mg/kg) were “obviously tremorgenic”.
See also
References
- ^ Bartlett, M. F.; Dickel, D. F.; Taylor, W. I. (1958). “The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine – Journal of the American Chemical Society (ACS Publications)”. Journal of the American Chemical Society. 80 (1): 126–136. doi:10.1021/ja01534a036.
- ^ Kuehne, Martin E.; Reider, Paul J. (1985). “A synthesis of ibogamine – The Journal of Organic Chemistry (ACS Publications)”. The Journal of Organic Chemistry. 50 (9): 1464–1467. doi:10.1021/jo00209a020.
- ^ Levi MS, Borne RF (October 2002). “A review of chemical agents in the pharmacotherapy of addiction”. Curr. Med. Chem. 9 (20): 1807–18. doi:10.2174/0929867023368980. PMID 12369879.
- ^ Jump up to:a b Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (September 1994). “Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum”. Brain Res. 657 (1–2): 14–22. doi:10.1016/0006-8993(94)90948-2. PMID 7820611.
From Wikipedia, the free encyclopedia
Clinical data | |
---|---|
ATC code |
|
Identifiers | |
CAS Number | |
PubChem CID | |
ChemSpider | |
ChEBI | |
Chemical and physical data | |
Formula | C19H24N2 |
Molar mass | 280.41 g/mol g·mol−1 |
(what is this?) (verify) |
Categories:
Related Posts
Quit Smoking Whit Ibogaine
How Ibogaine Products from Iboga World Can Assist in Quitting Smoking The journey to quit
Ibogaine Review Stan
Review of Iboga World’s Ibogaine Treatment by Stan Stan shares his experience with Iboga World’s
Opioid Addiction and Its Treatment
Opioid Addiction and Its Treatment A new statistics posted with the aid of the Centers