Ibogaine Ibogaline

Ibogaine Ibogaline

an alkaloid found in Tabernanthe iboga along with the related chemical compounds ibogaineibogamine, and other minor alkaloids. It is a relatively smaller component of Tabernanthe iboga root bark total alkaloids (TA) content. The percentage of ibogaline in T. Iboga root bark is up to 15% TA with ibogaine constituting 80% of the alkaloids and ibogamine up to 5%. In rodents, ibogaline induces more body tremor and ataxia compared to ibogaine and ibogamine. Among a series of iboga and harmala alkaloids evaluated in rats, the study authors found the following order of potency in causing tremors: A subsequent study confirmed these findings.

See also


  1. ^ Piotr Popik, Phil Skolnick (1998). Pharmacology of Ibogaine and Ibogaine-Related AlkaloidsThe Alkaloids52. San Diego.
  2. ^ Norbert Neuss (1959). “Notes- Alkaloids from Apocynaceae II. Ibogaline, A New Alkaloid From Tabernanthe Iboga Baill”. J. Org. Chem24 (12): 2047–2048. doi:10.1021/jo01094a622.
  3. Jump up to:a b Zetler G, Singbartl G, Schlosser L (1972). “Cerebral Phamacokinetics of Tremor-producing Harmala and Iboga Alkaloids”. Pharmacology7 (4): 237–248. doi:10.1159/000136294PMID 5077309.
  4. ^ Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN (1994). “Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum”. Brain Res657 (1–2): 14–22. doi:10.1016/0006-8993(94)90948-2PMID 7820611.
IUPAC name
Other names
3D model (JSmol)
PubChem CID
Molar mass 340.467 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
iboga inquiry

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