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Ibogaine – Metabolites

Ibogaine is metabolized in the human body by cytochrome P450 2D6, and the major metabolite is noribogaine (12-hydroxyibogamine). Noribogaine is most potent as a serotonin reuptake inhibitor and acts as a moderate κ- and weak µ-opioid receptor full agonist and therefore, also has an aspect of an opiate replacement similar to compounds like methadone. It is possible that this action of noribogaine at the kappa opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; salvia divinorum, another plant recognized for its strong hallucinogenic properties, contains the chemical salvinorin-A which is a highly selective kappa opioid agonist. Both ibogaine and noribogaine have a plasma half-life of around two hours in the rat, although the half-life of noribogaine is slightly longer than the parent compound. It is proposed that ibogaine is deposited in fat and metabolized into noribogaine as it is shows higher plasma levels than ibogaine and may therefore be detected for longer periods of time than ibogaine. Noribogaine is also more potent than ibogaine in rat drug discrimination assays when tested for the subjective effects of ibogaine. The Noribogaine differs from ibogaine in that it contains a hydroxy instead of a methoxy group at the 12 position
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Ibogaine – Research

An ibogaine research project was funded by the US National Institute on Drug Abuse in the early 1990s. The National Institute on Drug Abuse (NIDA) abandoned efforts to continue this project into clinical studies in 1995, citing other reports that suggested a risk of brain damage with extremely high doses and fatal heart arrhythmia in patients having a history of health problems, as well as inadequate funding for ibogaine development within their budget. However, NIDA funding for ibogaine research continues in indirect grants often cited in peer-reviewed ibogaine publications. In addition, after years of work and a number of significant changes to the original protocol, on August 17, 2006, a MAPS-sponsored research team received "unconditional approval" from a Canadian Institutional Review Board (IRB) to proceed with a long-term observational case study that will examine changes in substance use in 20 consecutive people seeking ibogaine-based therapy for opiate dependence at the Iboga Therapy House in British Columbia, Canada. Addiction treatment The most-studied therapeutic effect of ibogaine is the reduction or elimination of addiction to opioids. An integral effect is the alleviation of symptoms of opioid withdrawal. Research also suggests that ibogaine may be useful in treating dependence on other substances such as alcohol, methamphetamine, and nicotine, and may affect compulsive behavioral patterns not involving substance abuse or chemical dependence. Researchers note that there remains a "need for systematic investigation in a conventional clinical research setting." Many users of ibogaine report experiencing visual phenomena during a waking dream state, such as instructive replays of life events that led to…
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Ibogaine – Legal status

Ibogaine and its salts were regulated by the Food and Drug Administration in 1967 pursuant to its enhanced authority to regulate stimulants, depressants, and hallucinogens granted by the 1965 Drug Abuse Control Amendments (DACA) to the Federal Food, Drug, and Cosmetic Act. In 1970, with the passage of the Controlled Substances Act, it was classified as a Schedule I-controlled substance in the United States, along with other psychedelics such as DMT and mescaline. Since that time, several other countries, including Sweden, Denmark, Belgium, and Switzerland, have also banned the sale and possession of ibogaine. Although illegal in these countries, ibogaine has been used by hundreds of drug dependents in the United States and abroad. Howard Lotsof, a pioneer in bringing awareness to ibogaine's success in helping hardcore drug dependents to quit their addiction, and others have been offering willing persons the treatment. In the Czech Republic and Slovenia, taking advantage of less prohibitive legal systems, ibogaine has been applied to people coming from the and other countries seeking a safe haven.
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Ibogaine – In popular culture

Ibogaine first appeared in popular culture in the writings of Hunter S. Thompson. While covering the Wisconsin primaries of the 1972 Presidential primaries for Rolling Stone magazine, Thompson claimed that presidential candidate Edmund Muskie showed symptoms of being under the influence of Ibogaine. This assertion was later revealed by Thompson to be false, one that he had planted as media bait. He himself was surprised when the leading media outlets picked up the story and ran with it. It also appeared in the seventh episode of the eleventh season of Law & Order: Special Victims Unit. In the episode, Doctor Huang administers Ibogaine to a heroin addict so that he can testify against a murderer
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Chemistry of Ibogaine

Recent studies have shown that the primary metabolite from Ibogaine itself interacts with numerous neuron receptor transporters and neuronal networks within the mobile network and in the activity of dopaminergic-dependent and independent modulation circuits. Ibogaine takes the brain activity back into a healthy balance. Ibogaine actions are reported to reduce dopamine concentrations in the body. This is evidenced by the presence of dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in larger quantities after Ibogaine administration. This action of Ibogaine is to reverse the impact of drug abuse of some highly addictive drugs, Name: * Cocaine * Morphine * Amphetamines * Crack cocaine * Nicotine * Alcohol All these drugs act on dopamine dopaminergic systems and stimulate the body. Ibogaine is a tryptamine. It has two separate chiral centers, meaning that there are four different stereoisomers of ibogaine. These four isomers are difficult to resolve. Synthesis One recent total synthesis of ibogaine and related drugs starts with 2-iodo-4-methoxyaniline which is reacted with triethyl((4-(triethylsilyl)but-3-yn-1-yl)oxy)silane using palladium acetate in DMF to form 2-(triethylsilyl)-3-(2-((triethylsilyl)oxy)ethyl)-1H-indole. This is converted using N-iodosuccinamide and then fluoride to form 2-(2-iodo-1H-indol-3-yl)ethanol. This is treated with iodine, triphenyl phosphine, and imidazole to form 2-iodo-3-(2-iodoethyl)-1H-indole. Then, using 7-ethyl-2-azabicyclooct-5-ene and cesium carbonate in acetonitrile, the ibogaine precursor 7-ethyl-2-(2-(2-iodo-1H-indol-3-yl)ethyl)-2-azabicyclooct-5-ene is obtained. Using palladium acetate in DMF, the ibogaine is obtained. If the exo ethyl group on the 2-azabicyclooctane system in ibogaine is replaced with an endo ethyl, then epiibogaine is formed. Crystalline ibogaine hydrochloride is typically produced by semi-synthesis from voacangine in commercial laboratories. Derivatives A synthetic derivative of ibogaine, 18-methoxycoronaridine (18-MC), is a selective α3β4 antagonist that was developed collaboratively by the neurologist Stanley D. Glick…
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What is It Ibogaine?

Ibogaine is the psychoactive alkaloid from the root bark of the African bush Tabernanthe Iboga. Ibogaine is both a therapeutic and psychoactive addiction-breaker. In recent years the knowledge of Ibogaine has increasingly grown in breaking drug and alcohol addiction. Studies show that with only a single administration of Ibogaine, withdrawal symptoms are significantly reduced or in some cases even removed. Research shows that the desire for drug of choice is eliminated for either a long period of time or forever. The psychoactive properties of Ibogaine simulates a high spiritual awareness, It helps you to decipher problems in your life that may have lead you to taking drugs in the first place. Once those problems are identified and understood you can move forward and live drug free lives. Studies endorse that Ibogaine has considerable potential in the treatment of hard drug addiction for example heroin, suboxone, methadone, cocaine, crack and alcohol. There are also indications that it may be useful in the treatment of tobacco addiction. Ibogaine also offers opportunities as psychotherapy and/or spiritual teacher. In the field of psychotherapy, Ibogaine can be used as a treatment for the effects of trauma or conditioning, like asthma, cornice pain etc. The difference between Ibogaine and Iboga root bark is that the root bark alkaloids contain and include the Ibogaine Tabernanthe alkaloids which are extracted from the Iboga root bark. Ibogaine extract contains only scientifically recognized alkaloid with the known actions. Iboga World Iboga World specializes in and is committed to providing HIGH…
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Amy Jeanne

Hi Michelle, I just wanted you provide you an update on my husband's ibogaine experience. It has been seven days since he has taken his dose as per your direction. His experience under the influence, was very difficult.  However, with the guidance, support and research that I had done, I was able to offer plenty of comfort and reassurance as his journey appeared to be a typical one. Ibogaine delivered it's promise to him.  He is happily prepared to take his booster dose this evening as he is truly grateful for the gift it has given him.  Although, he doesn't speak at length about it (because he feels that it may be too good to be true), he is in utter disbelief at how much better he feels, mentally, physically and emotionally.  He says that his head is free of the debris that pesters him unrelentingly. He has no desire to drink - NONE. He says that he does not remember being as free and easy (in his mind) since early childhood (remember, he is now 48). From my perspective, he has proven that I have been correct that he is the man that I thought he was.  I have never believed that his negativity, impulsivity have been traits that he fostered - but rather traits that plagued him. I believed that addiction robbed me of my husband, but also robbed my husband of himself.  Ibogaine has set his brain straight.  He is back.  His dreams and ambition are back.…
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