Archives for Iboga Wiki
Ibogaine – Binding profile
Ibogaine has affinity (Ki) for the following sites in decreasing order of potency: σ2 (206 nM) > SERT ( nM) > DAT (1,980 nM) > NMDA (2,001 nM) > κ-opioid…
Ibogaine – Metabolites
Ibogaine is metabolized in the human body by cytochrome P450 2D6, and the major metabolite is noribogaine (12-hydroxyibogamine). Noribogaine is most potent as a serotonin reuptake inhibitor and acts as…
Ibogaine – Pharmacology
The pharmacology of ibogaine is quite complex, affecting many different neurotransmitter systems of its fairly low potency at any of its target sites, ibogaine is used in doses anywhere from…
Ibogaine – In popular culture
Ibogaine first appeared in popular culture in the writings of Hunter S. Thompson. While covering the Wisconsin primaries of the 1972 Presidential primaries for Rolling Stone magazine, Thompson claimed that…
Ibogaine – Research
An ibogaine research project was funded by the US National Institute on Drug Abuse in the early 1990s. The National Institute on Drug Abuse (NIDA) abandoned efforts to continue this…
Ibogaine – Legal status
Ibogaine and its salts were regulated by the Food and Drug Administration in 1967 pursuant to its enhanced authority to regulate stimulants, depressants, and hallucinogens granted by the 1965 Drug…
Ibogaine – Psychoactive effects
At doses of around 3–5 mg/kg of body weight, ibogaine has a mild stimulant effect. The high-dose ibogaine experience of 10 mg/kg or greater most commonly occurs as two distinct phases: the…
Drug
Drug Coffee is the most widely used psychoactive drug beverage in the world. In 1999 the average consumption of coffee was cups per day per citizen. Wine is a common…
Ibogaine – Pharmacodynamics
Among recent proposals for ibogaine mechanisms of action is activation of the glial cell line-derived neurotrophic factor (GDNF) pathway in the ventral tegmental area (VTA) of the brain. The work…
Ibogaine – Formulations
In Bwiti religious ceremonies, the rootbark is pulverized and swallowed in large amounts to produce intense psychoactive effects. In Africa, iboga rootbark is sometimes chewed, which releases small amounts of…