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Ibogaine – Binding profile

Ibogaine has affinity (Ki) for the following sites in decreasing order of potency: σ2 (206 nM) > SERT (548.7 nM) > DAT (1,980 nM) > NMDA (2,001 nM) > κ-opioid (2,717 nM) > µ-opioid (4,362 nM) > σ1 (5,839 nM) > M3 (12,500 nM) > 5-HT2A (14,142 nM) > M1 (22,486 nM) > M2 (39,409 nM) > D3 (70,000 nM).[42] It also has affinity for VMAT and the nACh receptors, among other targets
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Ibogaine – Metabolites

Ibogaine is metabolized in the human body by cytochrome P450 2D6, and the major metabolite is noribogaine (12-hydroxyibogamine). Noribogaine is most potent as a serotonin reuptake inhibitor and acts as a moderate κ- and weak µ-opioid receptor full agonist and therefore, also has an aspect of an opiate replacement similar to compounds like methadone. It is possible that this action of noribogaine at the kappa opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; salvia divinorum, another plant recognized for its strong hallucinogenic properties, contains the chemical salvinorin-A which is a highly selective kappa opioid agonist. Both ibogaine and noribogaine have a plasma half-life of around two hours in the rat, although the half-life of noribogaine is slightly longer than the parent compound. It is proposed that ibogaine is deposited in fat and metabolized into noribogaine as it is released.Noribogaine shows higher plasma levels than ibogaine and may therefore be detected for longer periods of time than ibogaine. Noribogaine is also more potent than ibogaine in rat drug discrimination assays when tested for the subjective effects of ibogaine. The Noribogaine differs from ibogaine in that it contains a hydroxy instead of a methoxy group at the 12 position

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Ibogaine – Pharmacology

The pharmacology of ibogaine is quite complex, affecting many different neurotransmitter systems simultaneously.Because of its fairly low potency at any of its target sites, ibogaine is used in doses anywhere from 5 mg/kg of body weight for a minor effect to 30 mg/kg in the cases of strong polysubstance addiction. It is unknown whether doses greater than 30 mg/kg in humans produce effects that are therapeutically beneficial, medically risky, or simply prolonged in duration. In animal neurotoxicity studies, there was no observable neurotoxicity of ibogaine at 25 mg/kg, but at 50 mg/kg, one-third of the rats had developed patches of neurodegeneration, and at doses of 75 mg/kg or above, all rats showed a characteristic pattern of degeneration of Purkinje neurons, mainly in the cerebellum. While caution should be exercised when extrapolating animal studies to humans, these results suggest that neurotoxicity of ibogaine is likely to be minimal when ibogaine is used in the 10–20 mg/kg range typical of drug addiction interruption treatment regimes, and indeed death from the other pharmacological actions of the alkaloids is likely to occur by the time the dose is high enough to produce consistent neurotoxic changes.

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Ibogaine – In popular culture

Ibogaine first appeared in popular culture in the writings of Hunter S. Thompson. While covering the Wisconsin primaries of the 1972 U.S. Presidential primaries for Rolling Stone magazine, Thompson claimed that presidential candidate Edmund Muskie showed symptoms of being under the influence of Ibogaine. This assertion was later revealed by Thompson to be false, one that he had planted as media bait. He himself was surprised when the leading media outlets picked up the story and ran with it.

It also appeared in the seventh episode of the eleventh season of Law & Order: Special Victims Unit. In the episode, Doctor Huang administers Ibogaine to a heroin addict so that he can testify against a murderer

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Testimonial Jasen

Jason

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Ibogaine – Research

An ibogaine research project was funded by the US National Institute on Drug Abuse in the early 1990s. The National Institute on Drug Abuse (NIDA) abandoned efforts to continue this project into clinical studies in 1995, citing other reports that suggested a risk of brain damage with extremely high doses and fatal heart arrhythmia in patients having a history of health problems,[citation needed] as well as inadequate funding for ibogaine development within their budget. However, NIDA funding for ibogaine research continues in indirect grants often cited in peer-reviewed ibogaine publications.

In addition, after years of work and a number of significant changes to the original protocol, on August 17, 2006, a MAPS-sponsored research team received “unconditional approval” from a Canadian Institutional Review Board (IRB) to proceed with a long-term observational case study that will examine changes in substance use in 20 consecutive people seeking ibogaine-based therapy for opiate dependence at the Iboga Therapy House in British Columbia, Canada.

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Ibogaine – Legal status

Ibogaine and its salts were regulated by the U.S. Food and Drug Administration in 1967 pursuant to its enhanced authority to regulate stimulants, depressants, and hallucinogens granted by the 1965 Drug Abuse Control Amendments (DACA) to the Federal Food, Drug, and Cosmetic Act. In 1970, with the passage of the Controlled Substances Act, it was classified as a Schedule I-controlled substance in the United States, along with other psychedelics such as DMT and mescaline. Since that time, several other countries, including Sweden, Denmark, Belgium, and Switzerland, have also banned the sale and possession of ibogaine. Although illegal in these countries, ibogaine has been used by hundreds of drug dependents in the United States and abroad. Howard Lotsof, a pioneer in bringing awareness to ibogaine’s success in helping hardcore drug dependents to quit their addiction, and others have been offering willing persons the treatment. In the Czech Republic and Slovenia, taking advantage of less prohibitive legal systems, ibogaine has been applied to people coming from the U.S. and other countries seeking a safe haven.

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Ibogaine – Psychoactive effects

At doses of around 3–5 mg/kg of body weight, ibogaine has a mild stimulant effect. The high-dose ibogaine experience of 10 mg/kg or greater most commonly occurs as two distinct phases: the visual phase and the introspective phase

The visual phase is characterized by open-eye visuals, closed-eye visuals, and dreamlike sequences. Objects may be seen as distorted, projecting tracers, or having moving colors or textures. When the eyes are closed, extremely detailed and vivid geometric and fractal visions may be seen. Subjective reports often include a movie-like recollection of earlier life experiences as well as dreamlike sequences with symbolism of one’s present or anticipated future. Other effects in the visionary phase may include laughing, sensations of euphoria or fear, and temporary short-term memory impairment. The visionary phase usually ends after one to four hours, after which the introspective phase begins.

The introspective phase is typically reported to bring elevated mood, a sense of calm and euphoria, and a distinct intellectual and emotional clarity. Subjects often report being able to accomplish deep emotional and intellectual introspection into psychological and emotional concerns. It is also during this period that opioid addicts first notice the absence of withdrawal symptoms or cravings. The duration of the introspective phase is highly variable, usually lasting hours but sometimes lasting days.

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Ibogaine Drug Treatment

Ibogaine Drug Treatment is a detox for drug addicts. It is painless and easy to do. Ibogaine will break your addiction instantly and allows its promotion of long-term drug abstinence. Iboga World sells Iboga Products so you can do the treatment in the convenience of your own home or where ever you like.

Ibogaine represents a very huge breakthrough for those in need of help. But there is also a level of risk involved in doing an ibogaine treatment. You may not experiment yourself because if Ingesting too much Ibogaine when you are very thin (low weight), or if you are suffering with liver or heart problems there will be dangers associated with an Iboga treatment. If you are unsure it is strongly advised to let your Liver and Heart be tested first. We from Iboga World will guide you with all you have to now and we are also able to work out a dosage for you.

If you decide to take ibogaine, you have to be aware of your dosage and which products to use so that you will have a successful treatment, and Iboga World will advise each individual separately. Iboga can definetly change your life and let you get rit of your Drug problems. So having an Ibogaine Drug-addiction breaking Treatment is wonderful to do to get clean and have a new and stable life.

Ibogaine Drug Treatment

When you start ingesting you will go sleep and you will be experience physical, psychological, and spiritual dimensions. This period will be various between 15 and 36 hours, this depends on what dose you will ingest and ofcourse each individual reacts differently because each person has a different metabolism. It doesn`t matter wich kind of drug addiction you have, an ibogaine treatment can make you get rid of each Drug Addiction there is. ( Heroin – Speed – Cocaine – Ecstasy – LSD – Tobacco – Alcohol )

Ibogaine Drug Treatment and Cravings

Ibogaine will reduce or eliminate drug cravings for a couple of months after ingesting a single dose treatment. Ibogaine will break down in the liver and change to a substance called Nor-ibogaine. The Nor-ibogaine will stay active in the opiate receptors for several months so you can stay away from the drugs you are using. Clinical researches shown that Nor-ibogaine will reduce cravings and it will create a window of opportunity, in which you will be able to learn the skills you need to stay clean from drugs and start your new life.

Iboga World can help you and shall guide you from the first time you contact us. Don`t hesitate any longer! Contact us through the contact page and we will answer all the questions you want to now before starting an Ibogaine Drug Treatment.

 

How Iboga have changed my life

Hello Iboga World and Michelle. It`s so amazing how Iboga have changed my
life.
It is hardly to believe but it`s a fact, and i have to say i have a life now
because of you all at Iboga World.
For the past 24 years i was an Heroin addict ( i am 48 now ) and living as
an Heroin addict is hard. But even i always new that the heroin destroyed me
and my life i had years and years ago i never had the change or the strain t
to get rid of it.
Lost almost all my friends, and only had some addict friends but that was
not what i needed.
So then one day a couple of months ago i contacted you Iboga World and there
was Michelle, she answered my first mail and my second an my third, there
she asked me if she could call me on the phone to discuss with me what iboga
could do for me.
She answered all my questions even the ones i did not ask, Michelle you are
really great. Then i ordered the Iboga products for my treatment, and i have
to say i wash also impressed how soon the Courier wash at my doorstep. So
then I have called my sitter and said the iboga was arrived and if we could
start the treatment as soon as she had the time. That was 2 days later. I
have undergo the treatment and 3 days later I was reborn and felt like I
never had felt before.
Now these days I have a good life a job and most of all a reason to life
again.
I really don`t now how I can Thank You all at Iboga World. I say it again
its because of you that I have a life. I hope this story will help other
addicts to get in contact with Iboga World and to start getting there life
back. Michelle specially you, you are always in my thoughts, without you i
never had the change to life again. I hope you will spread this story to
your customers or post it on your website. Iboga World rocks.

Lovely greetings

Ricardo Taylor